General Information

  • ID:  hor003140
  • Uniprot ID:  P86443
  • Protein name:  Neuropeptide F
  • Gene name:  NA
  • Organism:  Schistocerca gregaria (Desert locust) (Gryllus gregarius)
  • Family:  NPY family
  • Source:  animal
  • Expression:  Widely expressed in the nervous system. Expressed in corpora cardiaca, hypocerebral ganglion, frontal ganglion, protocerebrum, antennal lobe, tritocerebrum, thoracic ganglia, esophageal nerves, recurrent nerve and frontal connectives. Not detected in corp
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YSQVARPRF
  • Length:  9
  • Propeptide:  YSQVARPRF
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Accelerates ovarian maturation in females.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003140_AF2.pdbhor003140_ESM.pdb

Physical Information

Mass: 126614 Formula: C51H78N16O13
Absent amino acids: CDEGHIKLMNTW Common amino acids: R
pI: 11.15 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -82.22 Boman Index: -3009
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 43.33
Instability Index: 3493.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  11179815
  • Title:  Newly Discovered Functions for Some Myotropic Neuropeptides in Locusts.
  • PubMed ID:  19456328
  • Title:  Identification of New Members of the (Short) Neuropeptide F Family in Locusts and Caenorhabditis Elegans.
  • PubMed ID:  19524670
  • Title:  Peptidomic Survey of the Locust Neuroendocrine System